SANTA CLARA — Safety Talanoa Hufanga’s return from a knee injury that ended his 2023 season may have to wait.

Hufanga is listed as questionable on the 49ers’ official Week 1 injury report, which the team released Saturday afternoon. San Francisco opens the season Monday night against the New York Jets at Levi’s Stadium.

Defensive end Yetur Gross-Matos (knee) and linebacker Dee Winters (ankle) were left out.

Running back Christian McCaffrey has been cleared for action but is listed as questionable. He was listed as limited in practice this week due to calf and Achilles issues. Left guard Aaron Banks (finger) is also listed as questionable.

McCaffrey and Banks are expected to be available for Monday’s game.

Hufanga, who is entering his fourth NFL season, has a spot on the 49ers’ 53-man roster and was cleared to return to practice last week. He participated in a limited workout this week.

Hufanga tore an anterior cruciate ligament in his right knee on November 19 during a non-contact play while attempting to tackle Tampa Bay Buccaneers running back Rachaad White in the open field. Hufanga underwent surgery later that week.

Hufanga was placed on the list of players who were physically unable to play at the opening of training camp and was not fully cleared for medical until August 27, when teams were required to cut their rosters to the regular-season limit.

The 49ers are expected to use George Odum in Hufanga’s starting position against Aaron Rodgers and the Jets in Week 1. Ji’Ayir Brown, a second-year pro, is the permanent starter at the other safety position.

The 49ers could opt to promote two practice squad players for Monday’s game. Defensive end Sam Okuayinonu could take Gross-Matos’ spot on the depth chart. Safety Tracy Walker III is also a candidate.

Rookie Malik Mustapha is the fourth safety on the 49ers’ 53-man roster.

The 49ers also must make a roster move by 1 p.m. PT on Monday to activate All-Pro left tackle Trent Williams from the reserve/undeclared list.

Williams was a holdout in training camp due to contract issues. He agreed to a new deal with the team on Monday, but he remained on the reserve list because the 49ers were granted a temporary roster exemption.

49ers injury report

Out

THE Yetur Gross-Matos (knee)

LB Dee Winters (single)

Doubtful

S Talanoa Hufanga (knee)

Doubtful

RB Christian McCaffrey (calf, Achilles) G Aaron Banks (finger)

Jets Injury Report

Out

LB Zaire Barnes (ankles)

G Wes Schweitzer (hand)

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