LOS ANGELES — Shohei Ohtani, Tommy Edman, Will Smith and Max Muncy all hit home runs in the opening inning for the Los Angeles Dodgers on Wednesday night, the first time in franchise history that’s happened.

Ohtani led off the game with his career-best 47th home run ever, a 405-foot shot to center field off Chicago Cubs starter Jordan Wicks. The Japanese superstar hit his 48th stolen base in the second. He is three homers and two steals away from becoming the first player in Major League Baseball history to have a 50-50 season.

Two outs later, Teoscar Hernández singled and scored on Edman’s home run into the left-field pavilion off Wicks’ first pitch. Edman homered twice on two pitches against the Cubs on Tuesday.

Smith followed with a 404-foot shot to nearly the same spot in left. Muncy came next, sending a towering 401-foot blast to right on his bobblehead night.

The Dodgers overcame a 2-0 deficit to take a 5-2 lead.

It’s the second time this season that the Dodgers have gone four deep in an inning. The first was on June 11 in the sixth inning against the Texas Rangers in Los Angeles.

It also marks the second time this season that the Dodgers have gone back-to-back-to-back in the first inning, with Ohtani, Mookie Betts and Freddie Freeman doing the damage on Aug. 31 against the Diamondbacks. They are the first team to hit back-to-back-to-back home runs in the first inning of multiple games in a season since the 1994 Braves.

This report uses information from ESPN Research and The Associated Press.