GLENDALE, Ariz. — Los Angeles Rams wide receiver Cooper Kupp injured his ankle in the second quarter of Sunday’s game against the Arizona Cardinals and is unlikely to return.

Kupp appeared to suffer the injury on his fourth catch of the game — a 24-yard catch-and-run late in the first half. He walked off the field to the locker room at halftime with a noticeable limp.

The Rams are already without wide receiver Puka Nacua, who is on the injured list after spraining his posterior cruciate ligament in Week 1.

Kupp had four catches for 37 yards on six targets against the Cardinals before being forced off the field.

Through two games this season, Kupp has 18 catches for 147 yards and a touchdown.