Oregon has had two Big Ten games to welcome back to the conference, but this weekend’s showdown against the Ohio State Buckeyes will be its biggest challenge yet.

Can QB Dillon Gabriel and the Ducks continue their success and improve to 6-0? Or will the Buckeyes remain undefeated as they travel to Autzen Stadium in one of the most anticipated games of the year?

Oregon vs. Ohio State prediction and best bets

• Ohio State -3 (-110 at Fanatics Sportsbook)
• Total number of points in the first quarter more than 10.5 (+100 at BetMGM Sportsbook)
• Both teams score more than 20 points: Yes (-180 at DraftKings Sportsbook)

Despite the Ducks being one of the top teams in college football, the Buckeyes seem to be one of the few teams that are better. With a dominant rushing attack featuring RB Quinshon Judkins and TreVeyon Henderson, the Ohio State offense should be able to sustain drives and win the battle for time of possession.

Oregon’s close-call game against Boise State sticks out in my mind, when the Broncos were able to break through the Ducks’ defense, and it led to a 37-34 barnburner. While Oregon will likely come out with better focus and motivation, it may not have as much luck against a talented Ohio State team.

Through each of their first five games, both teams have put up first-quarter scores. So whether it’s one side or both, the teams share the performance, this game should yield some early points, and BetMGM is offering the cutoff at +100.

From there, the transition to both programs, ultimately exceeding the 20-point mark, seems feasible. In slow-paced grudge matches or high-scoring affairs, both offenses have what it takes to stay efficient. That should remain the case on Saturday.

Ohio State vs. Oregon CFB Week 7 Odds

The Ducks enter this game as the underdogs as sportsbooks favor Ohio State in this game by 3 to 3.5 points depending on the platform.

If you’re betting directly on who will win, Oregon has a moneyline ranging from +125 to +140, while Ohio State’s ranges from -150 to -165.

The over/under for the game is set at 54 or 54.5 depending on the platform.

Ohio State vs. Oregon moneyline odds analysis

Why Ohio State could be the favorite to win

Best odds: -150 moneyline with Fanatics sportsbook

When it comes to the Buckeyes, there may not be a roster filled with more talent in college football.

After a disappointing 2023 campaign, many expected NFL picks opted to return with the motivation and intent to win a championship this season. With QB Will Howard, RB Quinshon Judkins, S Caleb Downs and WR Jeremiah Smith joining the roster, the team has become loaded.

The trenches are very impressive on both sides of the football, whether it’s the offensive line buying time for playmakers to capitalize, or the front seven applying pressure and smothering teams to an FBS low of 202.4 yards per game .

This Ohio State team has it all, and it should play to their advantage this weekend.

Why Oregon could win as an underdog

Best odds: +140 moneyline with Caesars sportsbook

The big factor working in Oregon’s favor heading into Saturday’s game is Gabriel. While the passer may not be as flashy or athletic as some of the biggest names in college football, his efficiency is built to win close games.

Oregon has weapons including WR Tez Johnson, WR Evan Stewart and TE Terrance Ferguson. They all have splash play potential on any route, which can help create opportunities where the game can break in their favor.

Additionally, Oregon’s pass defense is impressive. Opposing quarterbacks are completing 53.4% ​​of passes against the Ducks. The Ducks defense could cause the Buckeyes offense to lose its rhythm and generate opportunities for Oregon to ease the upset at home.