US bombers have arrived in the Middle East region as tensions flare over Iran and may launch a new attack on Israel, the United States Central Command (CENTCOM) confirmed early Sunday.

B-52 Stratofortress strategic bombers from Minot Air Force Base’s 5th Bomb Wing arrived in the Middle East, CENTCOM said, without elaborating.

Pentagon officials previously said B-52 long-range bombers, along with more destroyers, fighter squadrons and tankers, would be deployed to the region to deter Iran and its militant allies.

The moves come ahead of Tuesday’s US presidential election and as the entire Middle East region teeters on the brink of becoming embroiled in a broader regional conflict over the ongoing clashes between Israel and Iranian allies Hamas and Hezbollah in Gaza and Lebanon.

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CENTCOM shared a photo of a B-52 Stratofortress strategic bomber in a social media post confirming the bombers arrived in the Middle East early Sunday. (US Central Command (CENTCOM))

Iran’s Supreme Leader Ayatollah Ali Khamenei on Saturday threatened Israel and the US with “a crushing response” after Israeli attacks on October 26 that targeted military bases and other locations and killed at least five people in the Islamic Republic.

Iran’s Supreme Leader Ayatollah Ali Khamenei threatened the US and Israel on Saturday. (ATTA KENARE/AFP via Getty Image, file)

“The enemies, whether it is the Zionist regime or the United States of America, will certainly receive a crushing response to what they are doing to Iran, the Iranian nation and the resistance front,” Khamenei said in a video released by Iranian state media .

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Khamenei did not elaborate on when such an attack might occur or its potential scale.

Iran had already launched two major direct attacks on Israel in April and October. In the latest attack, Iran launched nearly 200 ballistic missiles at targets in Israel.

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Meanwhile, the U.S. military last month sent Israel a U.S. missile defense system, Terminal High Altitude Area Defense, or THAAD, aimed at protecting Israel from possible Iranian attacks.

The Associated Press contributed to this report.