Data Write

The San Francisco 49ers (5-4) are the favorites – they are expected to win by at least a field goal, but less than a touchdown (currently -6) – against the Seattle Seahawks (4-5) in a matchup of two rivals from the division. The projected point total for the matchup is set at 48.5.

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New Mexico’s Eli Sanders takes it 26 yards for a tying rushing touchdown against Washington State

New Mexico Lobos’ Eli Sanders’ 26-yard rushing touchdown tied the score at 28-28 against the Washington State Cougars.

49ers vs. Seahawks Prediction and Picks

• Choose ATS: 49ers (-6)
  
• Choose OE: Under (48.5)
  
• Prediction:
  49ers 28-Seahawks 20
  

How to watch San Francisco vs. Seattle

• Game date: Sunday November 17, 2024
• Time: 4:05 PM ET
• Location: Levi’s Stadium
• Location: Santa Clara, California
• TV: Watch on FOX
• Live Box Score: FOX Sports

Read more NFL predictions for this week

49ers vs. Seahawks Recent Matchups

• San Francisco has a 5-0 record against Seattle in their last five games.
• Over their last five head-to-head games, San Francisco has scored 157 points while Seattle has put up 89.

San Francisco betting information

• San Francisco has four wins in nine games against the spread this year.
• The 49ers were favored by six points or more four times this season and were able to cover the spread in one of those games.
• San Francisco games have exceeded the total in five of nine opportunities this year (55.6%).
• The 49ers have posted a 5-4 record in the games they have played as moneyline favorites (winning 55.6% of those games).
• Based on the moneyline of this game, the 49ers’ implied probability of winning is 72.1%.

49ers stats

San Francisco’s key players

Offence

• Brock Purdy ranks sixth in the NFL with 2,454 passing yards in nine games this year, averaging 272.7 per game with a 65.1% completion percentage and 12 touchdowns (10th in the NFL) against seven interceptions.
• He has added 227 rushing yards (25.2 per game) and three touchdowns on the ground.
• George Kittle has caught 43 passes on 53 targets for 560 yards and seven touchdowns. He is averaging 5.4 catches and 70 yards per game through eight games.
• Jordan Mason has 690 rushing yards (ninth in the NFL) with three touchdowns (76.7 yards per game across nine games).
• Jauan Jennings is averaging 4.6 receptions and 71 yards per game, and has totaled 497 receiving yards and 32 catches. He has totaled 47 targets and caught three touchdown passes.

Defense

• On defense, Fred Warner has 75 tackles, three TFLs, one sack and two interceptions in 2024.
• Nick Bosa has 32 tackles, eight TFL, 5.5 sacks and one interception this season.
• Deommodore Lenoir has collected 53 tackles, one TFL and two interceptions this year.
• Ji’Ayir Brown has one interception while tacking on 45 tackles, three TFL and four passes defended.

Seattle betting information

• Seattle is 2-7-0 against the spread this year.
• Seattle games have exceeded the total five times this season.
• The Seahawks have won one of the five games they have played as underdogs this season.
• Oddsmakers have suggested with the moneyline for this matchup that the Seahawks have a 32.3% chance of winning.

Seahawks stats

Seattle’s key players

Offence

• Geno Smith has passed for 2,560 yards this year (which ranks fourth in the NFL), with 11 touchdowns and 10 interceptions. He is completing 68.1% of his attempts while averaging 284.4 yards per game and 7.5 yards per attempt.
• He has added 193 yards on the ground (third on the Seahawks), with one rushing touchdown. He is averaging 21.4 yards per game and 5.4 yards per attempt.
• Kenneth Walker III is averaging 56.9 rushing yards per game through seven games (398 total yards) while scoring six rushing touchdowns.
• Walker has also amassed 217 receiving yards (31 per game) on 30 catches (4.3 per game). He has been targeted 34 times and has caught one touchdown pass.
• Jaxon Smith-Njigba has totaled 568 receiving yards and three touchdowns on 50 receptions while being targeted 75 times this season.
• DK Metcalf has been targeted 61 times, resulting in 35 catches for 568 yards.

Defense

• Julian Love has recorded two TFLs, 65 tackles and two interceptions in nine games in 2024.
• Ernest Jones has 68 tackles, four TFL and three passes defensed.
• During the 2024 campaign, Derick Hall has 25 tackles, three TFL and five sacks in nine games.
• Devon Witherspoon has totaled one TFL and 51 tackles in nine games.

FOX Sports created this story using technology from Data Skrive and data from Sportradar.

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San Francisco 49ers

Seattle Seahawks