Christina Applegate shared a raw look at the physical side of multiple sclerosis and how the disease often leaves her ‘screaming’ in pain.

“I was in bed screaming – like the sharp pain, the pain, that squeezing,” the Dead to me actress said, revealing that her symptoms have worsened during the Nov. 5 episode of MeSsy, the podcast she co-hosts with Jamie-Lynn Sigler, who also has MS.

In the episode, the pair spoke to Rory Kandel, the owner of Rory’s Bakehouse, who said her MS also “manifests itself as pain.”

“It feels like I have knives in my stomach,” Kandel said. “Like, I’m in bed, and I wake up, and I physically can’t turn back and forth.”

“It’s the worst,” said Applegate, who was diagnosed with multiple sclerosis in 2021. The Cleveland Clinic explains that the progressive disease “damages the protective covering around the nerves, called myelin, in your central nervous system. It can cause muscle weakness, vision changes, numbness and memory problems.”

“Do you feel that way?” Kandel asked, prompting Applegate to respond, “Every day of my life.”

“Sometimes I can’t even answer my phone because it’s in my hands now, so I’ll try to grab my phone or grab my remote to turn on the TV, or sometimes I can’t even hold them. open more bottles.”

“But we look good,” Kandel said.

“Because it’s the beauty of the invisible disease,” Applegate said.

The Married…with children alum shared that depending on her pain level, “I would just lay in bed the whole time. I mean, I’ve worked for almost 50 years, so I’m okay with it.”

Getting out of bed in the morning can be so painful that Applegate compared it to the “floor is lava.” The floor is made of lava.”

“It looks like someone stuck a hot poker in my hole,” Sigler said of those first steps of the day.

“I put my feet on the ground and they are extremely painful to touch,” Applegate said. “I was like, yeah. I’m going to lie back in bed and wet my diaper because I don’t feel like walking all the way to that damn bathroom,” she said, quickly adding, “I’m not actually going to lie down here and peeing in my bed diaper. That’s just a joke.”

“But it’s like it’s so incredibly painful and so hard and so uncomfortable.”

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