Chiefs storyline to watch: In seven career games against the Chiefs, three of which will be counted in the playoffs, quarterback Josh Allen has 16 touchdown passes, three interceptions and a QBR of 74. Can the Chiefs keep him from another big game this time, even if Allen to a group of receivers depleted by injuries? Over the past two weeks, the Chiefs have offered little resistance against Tampa Bay’s Baker Mayfield and Denver’s Bo Nix. –Adam Teicher

Bills storyline to watch: Can the Bills defense continue to limit the Chiefs offense in the regular season? The Bills have held the Chiefs to 20.8 points per game in four regular season meetings since 2020. Taking the ball away is a focus for this defense and could be the key to success. The Bills have 12 consecutive games with at least one takeaway, the second-longest active streak in the NFL behind the Lions (13). — Alaina Getzenberg

Statistic to know: The Bills have won five straight games; Buffalo’s plus-61 scoring margin during the win streak is the third highest of any team in the NFL over that span, behind only the Lions (plus-91) and the Eagles (plus-82)

Bold prediction: Bills cornerback Christian Benford takes on quarterback Patrick Mahomes. Benford is playing great this season. In fact, no outside cornerback has allowed fewer yards per coverage snap (0.6) than him, according to NFL Next Gen Stats. Part of that is because he’s allowing fewer targets than average (13%), but also because he’s allowed a minus 9% completion rate above expectations. –Walder

Fantasy X Factor: Chiefs chasing Kareem Hunt. Kansas City has the first possession (33:01), which means we should see a lot of Hunt. He has had more than 20 touches in each of his past four games and scored at least 17 fantasy points in three of them. The Bills defense is allowing the second-most fantasy points per game to running backs. See the week 11 rankings. — Moody

Bet: The Chiefs are 0-4 ATS in their past four conference games.

Kahler’s choice: Bills 29, Chiefs 27

Moody’s choice: Bills 25, Chiefs 23

Walder’s choice: Bills 24, Chiefs 17

FPI prediction: BUF, 53.1% (average 1.4 points)