Ozempic is no laughing matter for the comedian. Handler revealed that her “anti-aging doctor” prescribed the medication without her realizing what the drug was.

“I didn’t even know I was doing it,” she said during the January 25, 2023 episode of Call her daddy. “She said, ‘If you ever want to lose five pounds, this is good.'”

But while she tried the drug, Handler noticed that she didn’t like the feeling.

“I came back from vacation and injected myself with it,” she recalls. “A few days later I went to lunch with a friend and she said, ‘I’m not really eating anything. I’m so nauseous, I’m taking Ozempic.’ And I thought, ‘I’m a little nauseous too.’ But I had just come back from Spain and was jet lagged.”

Ultimately, Handler stopped taking the drug because it was not medically necessary for her, adding that she gave away the remaining doses to friends.

“I injected about four or five of my friends with Ozempic because I realized I didn’t want to use it because it was stupid,” she said. “It’s for heavy people. People come to my house and I say, ‘Okay, I’ll see you at 1 o’clock, I’ll see you at 2 o’clock.'”