The LA Rams (0-1) are heading into a division match in week 2 against the Arizona Cardinals (0-1). Kickoff from State Farm Stadium is at 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Rams vs Cardinals chancesand make our expert NFL predictions.

The Rams opened their season with a 26-20 OT loss to the Detroit Lions on September 8, failing to cover as 5.5-point underdogs. The Under (53.5) cashed.

The Cardinals lost 34-28 at the Buffalo Bills in Week 1, covering themselves as 6.5-point underdogs. De Over (45) hit.

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Rams vs Cardinals Odds

Powered by BetMGM Sportsbook; visit USA TODAY Sports Scores and Sports Betting Odds hub for a complete list of NFL odds. Lines last updated Saturday at 2:05pm ET.

• Money Line (ML): Rams +100 (bet $100 to win $100) | Cardinals -120 (bet $120 to win $100)
• Against the spread (ATS): Aries +1 (-110) | Cardinals -1 (-110)
• Over/Under (O/U): 48 (O: -110 | U: -110)

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Rams at Cardinals major injuries

Rams

• G Steve Avila (knee) out
• AT Davis Allen (back) out
• OL Kevin Dotson (foot) doubtful
• CB Cobie Durant (teen) doubtful
• QB Jimmy Garoppolo (suspension) out
• AT Tyler Higbee (knee) out
• S Quentin Lake (hip) doubtful
• WR Puka Nacua (knee) out
• OT Joe Nootboom (only) out

Cardinals

• WR Zay Jones (suspension) out
• WR Xavier Wever (oblique) doubtful

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Rams at Cardinals Picks and Predictions

Prediction

Cardinals 24, Aries 20

Moneyline

The Cardinals (-120) haven’t beaten the Rams at home in 10 years and have won just twice against them since 2017.

But Detroit was able to run the ball in Week 1 against the Rams, and the Cardinals had a top-5 rushing offense last season, led by RB James Conner.

The Rams need just a third left winger and a backup center, as Noteboom and Avila both ended up on the injured list this week, along with Nacua.

It’s Arizona’s first home game, which should give the team some extra momentum.

The Cardinals will finally be off the hook, but the odds are better as the spread widens.

PASSAGE.

Against the spread

The Cardinals started the season 1-0 ATS. They built a 17-3 first-half lead against Buffalo last week, which then swept Miami on Thursday Night Football.

The Rams’ defense isn’t up to the same level as Buffalo’s right now.

WED CARDINALS -1 (-110).

Over/Under

Between Conner and Rams RB Kyren WilliamsThis could be a race that involves a lot of running, which will slow the pace.

Four of the last five meetings have failed to reach a total of 48 points.

BET UNDER 48 (-110).

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