Kyler Murray threw for 266 yards and three touchdowns, rookie receiver Marvin Harrison Jr. caught his first two NFL touchdown passes and the Arizona Cardinals defeated the Los Angeles Rams 41-10 on Sunday.

The Cardinals’ offense, highlighted by the Murray-Harrison combination, shined en route to a 24-3 halftime lead.

Murray found Harrison for a 23-yard touchdown on the first drive, a 60-yard touchdown on the second drive and then somehow eluded three Rams defenders before passing tight end Elijah Higgins for an 18-yard touchdown on the third drive for a 21-0 lead.

Arizona (1-1) snapped a nine-game losing streak against the Rams (0-2) at State Farm Stadium to win for the third time in 16 tries in NFC West competition.

James Conner ran for a five-yard score on the first drive of the third quarter, stepping high into the end zone for a 31-3 lead. Conner finished with 122 yards rushing, and the 29-year-old passed 5,000 yards on the ground for his career. Harrison had 130 yards receiving.

Dennis Gardeck had a pair of sacks. Matt Prater hit two field goals, including one from 57 yards, to make it 34-3.

While Arizona’s offense flourished, Los Angeles sputtered. Matthew Stafford was sacked three times in the first half and the Rams couldn’t find the end zone. On the final play of the second quarter, coach Sean McVay opted to go for a touchdown from the 4-yard line instead of kicking a field goal, but Stafford’s pass sailed well over Tyler Johnson’s head and out the back of the end zone.

To make matters worse, star receiver Cooper Kupp left the second quarter with an ankle injury and did not return. The Rams have had a bad run of injuries in the first two weeks, leaving three key players on the injured list this week.

Stafford completed 19 of 27 passes for 216 yards.

Harrison’s first NFL touchdown catch wasn’t an easy one. The rookie receiver made a tough catch in the back of the end zone, planted both feet and held the football as he fell to the ground.

The rookie — who was the No. 4 overall pick out of Ohio State — was back on the next drive. Murray rolled to his right before hitting the wide-open receiver, and the Cardinals had a 14-0 lead just six minutes into the game. Harrison became just the 13th receiver since 1991 to have at least 130 yards receiving in the first quarter.

Harrison was much more productive than in his debut last week, when he caught just one pass for 4 yards in a loss to the Bills.

The Cardinals took a 21-0 lead early in the second quarter after Murray missed three defenders and weaved through traffic before firing the ball to Higgins, who ran across the back of the end zone and made a sliding catch.

Rams: S John Johnson III (shoulder) left the field in the second half.

Rams: Host the San Francisco 49ers next Sunday.

Cardinals: Host the Detroit Lions next Sunday.