All Matthew Stafford needed was a chance.

The San Francisco 49ers gave the Rams’ veteran quarterback two chances in the closing minutes of Sunday’s game at SoFi Stadium and Stafford made them pay both times.

Stafford led a touchdown drive that tied the game, followed by a field goal drive that brought the Rams back to beat the 49ers 27-24 in front of a crowd of 74,484.

Joshua Karty hit a 37-yard field goal with two seconds left to give the Rams a win, extending their record to 1-2.

Kyren Williams scored two touchdowns and also caught a touchdown pass, helping the Rams avoid a 3-0 deficit.

San Francisco 49ers wide receiver Jauan Jennings catches the ball for Rams cornerback Cobie Durant.

(Wally Skalij / Los Angeles Times)

Stafford completed 16 of 26 passes for 221 yards and a touchdown. Williams rushed for 89 yards and two touchdowns in 24 carries. He caught two passes for 27 yards and a touchdown.

San Francisco quarterback Brock Purdy threw three touchdown passes to receiver Jauan Jennings, but it wasn’t enough to stop the Rams.

It was a key win for a Rams team that will be without injured receiver Cooper Kupp, who is out indefinitely, and receiver Puka Nacua, offensive linemen Steve Avila, Joe Noteboom and Jonah Jackson and defensive backs Darious Williams and John Johnson III, who are on the injured list.

The Rams quickly fell behind when Purdy scored two touchdowns with Jennings.

However, running back Ronnie Rivers’ run for a first down on a fake punt kept alive a Rams drive that Williams capped with a 14-yard reception, finishing with a somersault into the end zone.

The Rams got the ball early in the second half, but they needed to score. The 49ers took advantage of this by mounting a long scoring drive.

Purdy’s 31-yard touchdown pass to Jennings put the 49ers ahead, 21-7. After the Rams pulled within seven, the 49ers extended their lead to 10 points with a field goal early in the fourth quarter.

The Rams closed the score to 24-17 thanks to a 33-yard field goal by Joshua Karty with about six minutes left.

They got another chance when Jake Moody’s 55-yard field goal went wide left, giving Stafford the ball at the Rams’ 45-yard line.

Stafford completed a 50-yard pass to receiver Tutu Atwell, setting up Williams’ short touchdown run that tied the score, 24-24.

Xavier Smith’s 37-yard punt return led to Karty’s winning field goal after a crucial pass interference penalty against the 49ers.