• QB Brock Purdy, San Francisco 49ers — over 250.5 passing yards (-115): The young passer currently lays claim to the third-highest PFF grade (84.0) in the league and has managed to surpass that mark in three of his last four games.

• 2024 record: 11-13 (45.8%) — -2.14 units won.

• Unlock your edge with a PFF+ subscription: Get full access to all of our pre-season fantasy tools, including weekly rankings, WR/CB matchup charts, weekly projectionsthe Start-Sit Optimization and more. Register now!

Estimated reading time: 4 minutes

Game overview

Week 6 kicks off with a highly anticipated matchup between NFC West division rivals. Seattle holds first place in the division and hosts the reigning NFC champion 49ers.

While both franchises have strong rosters, that doesn’t equate to terribly solid results in the betting market, with both teams combining to win just three times in ten games. San Francisco has been able to pick up points every week at the start of the season and has especially struggled as road favorites, currently sitting at 0-2 against the spread. On the other sideline, the Seahawks are staring at an 0-2 record against the spread in their past two games.

Both teams are coming off straight home losses as seven-point favorites, with Seattle losing to the Giants by nine points and San Francisco falling to a late field goal in Arizona.

The 49ers’ problems in the red zone have become a topic of conversation again this week after another poor performance. Against the Cardinals last week, the team managed six trips to the red zone but came away with just one touchdown. The 49ers boast the fifth-lowest red zone touchdown percentage in the league (40.9%), despite having the highest average red zone snaps per game (14.2) in the NFL.

That could be a problem against this Seahawks defense, which seems to get stronger when backed inside its own 20-yard line. Despite allowing the second-most red zone drives (20), Seattle has only reduced its red zone touchdown rate to 45% – a top-10 mark among defenses. And most of that damage came in one game, on the road against Detroit.

However, Seattle has seen more favorable matchups that support this number a bit. While the 49ers have struggled in some respects, they are undoubtedly one of the most talented offenses the Seahawks will face this season.

WR DK Metcalf, Seattle Seahawks: Over 61.5 receiving yards (-110) — Variable PFF Greenline Edge

Despite some issues this past week, Metcalf has had a fantastic start to the season. The sixth-year receiver has seen 42 targets – a top-10 mark for the position – allowing him to produce at a high level. Metcalf has surpassed 100 receiving yards in three of his past four appearances, leading him to a top-25 rank in yards per route among receivers.

Tasked with guarding Metcalf will be the 49ers cornerback Charvarius districtwhich has a large gap to catch up after a difficult start to the year. Ward had just a PFF coverage grade of 43.2 over the past three games, ranking 92nd out of 99 qualifying cornerbacks.

In previous matchups between these two, Ward has generally gotten the upper hand over Metcalf, but this will be the Seahawks receiver’s chance to break that trend. In addition to his problems on the field, Ward is also dealing with a knee injury that has limited his training this week. Considering how Ward won this match through his physicality, being hampered by that injury could make it a much more difficult task to repeat.

QB Brock Purdy, San Francisco 49ers: Over 250.5 passing yards (-115) – 0.8% PFF Greenline Edge

While the 49ers have questions to answer about their offensive efficiency, Purdy is playing quality ball through the first five games. The young passer currently lays claim to the third-highest PFF grade (84.0) in the league and has managed to surpass that mark in three of his past four games.

Part of that is due to the 49ers playing well in pass protection, especially over the last two games. In Weeks 4 and 5, San Francisco’s pass protection has produced the eighth-best team pass blocking grade (76.3), after surrendering zero sacks and posting a top-10 pass blocking efficiency rating (85.4).

That could prove to be a problem for Seattle, where rapid production has fallen recently. Through the first three games, the Seahawks received the most pressures (70) in the NFL. But they have generated the fifth fewest over the past two weeks.

Without pressure, Purdy will have to parse a secondary that may not have a cornerback Riq Wollen (single), leaving the cornerback behind Tre Brown (41.8 PFF coverage grade over the past three games) in a tough spot.