This week’s NFL action kicks off with the San Francisco 49ers visiting the Seattle Seahawks on “Thursday Night Football” (8:15 p.m. ET, Prime Video).

Despite their 2-3 start, the 49ers remain the odds-on favorite to win the NFC West (-115), ahead of the Seahawks (+225), who sit atop the division at 3-2.

San Francisco has the best odds of any NFC team to win the Super Bowl (+750), is tied for second overall with the Baltimore Ravens and trails only the reigning champion Kansas City Chiefs (+450). The Seahawks are 40-1.

The line for Thursday’s matchup has held steady at 49ers -3.5, but the betting total has gone from 46.5 at the opener on ESPN BET to 49.5. ESPN’s Football Power Index likes the 49ers at 4.6, with an outright win rate of 61.9%.

Odds current as of publication time, courtesy of ESPN BET

Game lines

Spread: 49ers -3.5
Money line: 49ers (-185), Seahawks (+155)
Top/Bottom: 49.5

Distribution over the first half: 49ers -2.5 (-120), Seahawks +2.5 (-110)
Total points 49ers: 26.5 (over -120/under -110)
Total Seahawks points: 22.5 (over -115/under -115)

The props

Pass

Brock Purdy total passing yards: 249.5 (over -115/under -115)
Purdy total passing TDs: 1.5 (more than -135/less than +105)
Geno Smith’s total passing yards: 249.5 (over -115/under -115)
Smith’s total passing TDs: 1.5 (more than +100/less than -130)

Hurry

Jordan Mason total rushing yards: 79.5 (over -105/under -125)
Kenneth Walker III total rushing yards: 59.5 (over -135/under +105)
Zach Charbonnet total rushing yards: 14.5 (over -120/under -110)

Received

Brandon Aiyuk total receiving yards: 69.5 (over +105/under -135)
Deebo Samuel Sr. total receiving yards: 59.5 (over +105/under -135)
DK Metcalf total receiving yards: 59.5 (over -135/under +105)
George Kittle total receiving yards: 49.5 (over -110/under -120)
Jaxon Smith-Njigba total receiving yards: 44.5 (over -130/under +100)
Tyler Lockett total receiving yards: 44.5 (over -115/under -115)
Jauan Jennings total receiving yards: 29.5 (over -105/under -125)
Noah Fant total receiving yards: 24.5 (over +105/under -135)
Walker total receiving yards: 19.5 (over -135/under +105)

Anita Marks’ choice

play

Who can bounce back on Thursday: 49ers or Seahawks?

Marcus Spears previews Week 6’s Thursday night game between the 49ers and Seahawks.

49ers -3 (-135 after purchasing half a point)

The 49ers have won a total of five straight games against the Seahawks and are 4-0 against them (including playoffs) with Brock Purdy under center. Seattle raced to a 3-0 record to start the season, facing quarterbacks Bo Nix (Denver), Jacoby Brissett (New England), Skylar Thompson and Tim Boyle (Miami). The Seahawks won’t have that luxury against Purdy. Seattle, losers of two straight games, is playing its third game in 11 days and is coming off a short week after a physical matchup against the Giants. Not to mention defensive injuries, turnovers and penalty issues. The 49ers are rolling here.

Betting Trends

Courtesy of ESPN Stats and Info

• Seattle is 1-4 ATS this season, ranked worst in the NFL. Overs are 4-1 in Seahawks games.

• The 49ers have won five straight meetings (including playoffs), going 4-1 ATS. The Seahawks are 18-9 ATS in the last 27 meetings (including playoffs).

• The Seahawks are 17-6 ATS as home underdogs since 2011, including 4-2 ATS in Geno Smith’s start. Smith is 9-4 ATS in prime-time games (3-10 outright).

• Over the past five seasons, teams have suffered losses as the favorites by at least 7 points are 37-25 ATS in their next games (.597), including 4-1 ATS this year and 13-6 ATS the past two seasons. The 49ers lost at home last Sunday as touchdown favorites to the Cardinals.

• Brock Purdy was favored in all 26 regular-season starts this week, the longest streak to start a career in the Super Bowl era. He is 7-1 ATS when laying under four points.

• The home underdogs in Thursday games are 10-16 ATS since 2020.

More from ESPN