The Arizona Cardinals gave up 216 rushing yards and four touchdowns on the ground in a 42-14 loss to the Washington Commanders, dropping them to 1-3 and raising more questions about how well-rested both sides of the ball are in terms of talent.

Washington’s offense, led by coordinator and former head coach Kliff Kingsbury, attacked the Cardinals in the trenches, allowing Brian Robinson Jr. Returned 21 carries (101 yards).

The team signed Jeremy McNichols (eight carries, 68 yards) and got more out of quarterback Jayden Daniels (eight carries, 47 yards), the former Arizona State star who won a Heisman at LSU before becoming the second overall pick.

McDaniels went 26 for 30 for 233 yards, a touchdown and a pick.

Arizona quarterback Kyler Murray completed 16 of 22 passes for 142 yards and a touchdown, a game-opening drive after a charge on rookie receiver Marvin Harrison Jr.

But that was the brief lead for the Cardinals that day. They struggled to get pressure on Daniels, recording just one quarterback hit that day.

Meanwhile, Arizona gave up four sacks to Murray, plus three more quarterback hits. Despite 18 carries for 104 yards from running back James Conner, the Cardinals got few offensive contributions from their skill players.

With Trey McBride sidelined, the Cardinals saw Harrison finish with five catches for 45 yards, while second-year pro Michael Wilson and slot option Greg Dortch each added 38 receiving yards.

Follow @AZSports