The Chargers begin their new era against the opponent that ended their previous era.

After an embarrassing 42-point loss to the Oakland Raiders last December resulted in the firing of Brandon Staley, new head coach Jim Harbaugh will make his debut Saturday at SoFi Stadium against the AFC West rival. Beyond Harbaugh’s ever-present khakis, little seems certain about the new-look Chargers.

Quarterback Justin Herbert will work with new running backs and receivers behind an offensive line that will start rookie Joe Alt at tackle. The former No. 5 pick will be welcomed to the NFL by Raiders star edge rusher Maxx Crosby. The defense is set for a reboot under former Michigan defensive coordinator Jesse Minter.

The Chargers gave up 63 points in last year’s loss, allowing Raiders head coach Antonio Pierce to secure the permanent position, and safety Derwin James Jr. hasn’t forgotten that, circling this season opener as soon as he got the schedule.

“It’s Raiders week,” James said. “It means so much more.”