Christina Applegate doesn’t shy away from sharing the realities of life with multiple sclerosis.

The Anchorman actress, who was diagnosed with the autoimmune disease in 2021, revealed on Monday’s episode of her MesSy podcast with co-host Jamie-Lynn Sigler that she still deals with painful, physical symptoms of her condition every day.

“I was in bed screaming,” Applegate said. “Jamie and I have different – ​​everyone has different ways of showing it. I lay in bed screaming. Like the sharp pain, the pain, that pinching.

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The Mayo Clinic defines multiple sclerosis (MS) as a disease that occurs when the “immune system attacks the protective layer that covers nerve fibers, known as myelin.” It notes that symptoms can often include “numbness, weakness, difficulty walking and vision changes,” but that they can vary depending on “the person, the location of the damage to the nervous system and how bad the damage is to the nervous system. nerve fibers.” There is currently no cure.

Applegate’s symptoms surfaced on the podcast as part of her and Sigler’s conversation with guest Rory Kandel, a California bakery owner who has also been diagnosed with MS. The Rory’s Bakehouse founder noted that her own symptoms often “manifest themselves in pain,” which feels like she has “knives in your spine” that sometimes prevents her from moving.

“Do you feel that way?” She asked, to which Applegate replied, “Every day of my life.”

The Married… with children alum continued, “Sometimes I can’t even answer my phone because it’s in my hands right now. So I’ll try to grab my phone, or grab my remote to turn on the TV (and) sometimes I can’t even hold them. I can’t open bottles anymore now.”

Still, Kandel noted that no matter how painful their symptoms are, to the rest of the world they all seem outwardly healthy. Applegate added: “Because it is the beauty of the invisible disease.”

Later in their conversation, Applegate explained that she can always predict what the day will feel like for her depending on how easy it is to get out of bed.

“Jamie knows I was in bed the whole time. I mean, I’ve worked for almost 50 years, so I’m okay with it,” she said. “But when I put my feet on the ground and they feel extremely painful, I’m like, ‘Yes.’ I’m going to lie back in bed and wet my diaper because I don’t feel like walking all the way to that damn bathroom.’”

And before anyone says anything, Applegate clarified that her last comment was made in jest. “I’m not actually lying here peeing my diaper. That’s just a joke,” she said. “But it is so incredibly painful, so difficult and so uncomfortable.”

Listen to Applegate reflect on her symptoms in the podcast above.