It’s all on the agenda for Deion Sanders and the Colorado Buffaloes in their season opener Thursday night.

They enter their clash with North Dakota State as 10-point favorites on Fanatics Sportsbook and are the all-time favorites to win at -375.

The Division I AA school produced two top NFL draft picks, Carson Wentz and Trey Lance, and also brought Easton Stick into the league.

However, no top talent is expected for the Buffaloes on Thursday.

North Dakota State bizarrely employs a two-quarterback system, led by passing quarterback Cam Miller and supported by Cole Payton, who fills a role similar to the Saints’ Taysom Hill.

We’re going to bet on the first half against the spread.

Colorado vs. Prediction North Dakota State

Colorado will have to rely primarily on its defensive line this season.

The Buffaloes’ defense was among the best in college football last year and a total of nine of their top 11 players are back.

Colorado will need to improve its tackling and run defense to take a step forward this year, but that continuity and a revamped roster full of transfers should lead to an improved football team after last year’s disappointing 4-8 mark that saw several players collapse in close games.

Offensively, Colorado will need much better play from the offensive line to protect star quarterback Shedeur Sanders.

Thursday’s game could be his showpiece, giving him an early shot at the Heisman Trophy.

North Dakota’s defense, especially the secondary, is terrible.

Betting on American football?

Two-way star Travis Hunter could also make a leap forward at receiver. He’s one of the best at that position and also shines on defense as a lockdown cornerback.

The Buffaloes should ultimately take the lead in this game, but the defense could be busy with two different strategies and completely opposing attacks.

Coach Prime isn’t much of a star at managing the game.

I hope North Dakota State stays exciting in the first half, but how this will turn out in the second half remains to be seen.

PICK: North Dakota State first half spread +7.5 (-160, Fanatics)