The Detroit Pistons (0-1) visit the Cleveland Cavaliers (1-0) Friday. Tip-off from Rocket Mortgage FieldHouse is scheduled for 7:30 PM ET. Let’s round up BetMGM Sportsbook’s NBA odds Pistons vs. Cavaliers chances and make our expert NBA picks and predictions for the best bets.

Season Series: First Meeting; Cavaliers won 4-0 last season

Detroit dropped its season opener with a 115-109 loss to the Indiana Pacers on Wednesday, while failing to defend as a 5.5-point underdog. G Cade Cunningham scored a game-high 28 points, while C Jalen Duren (13 points, 13 rebounds) added a double-double. The Pistons shot 43.2% from the field in the loss.

Cleveland defeated the Toronto Raptors 136-106 in their Wednesday opener to become a 6.5-point road favorite. F Evan Mobley scored a game-high 25 points with 9 rebounds as the Cavs shot 58.6% from the field in the win.

Pistons vs. Cavaliers odds

Powered by BetMGM Sportsbook; For a full list of NBA odds, visit the USA TODAY Sports Scoring and Sports Betting Hub. Lines last updated at 10am ET.

• Moneyline (ML): Pistons +425 (bet $100 to win $425) | Cavaliers -600 (Bet $600 to win $100)
• Against the Spread (ATS): Pistons +10.5 (-105) | Cavaliers -10.5 (-115)
• Top/Bottom (O/U): 227.5 (E: -115 | U: -105)

Pistons in Cavaliers main injuries

Pistons

• F Ausar Thompson (conditioning) off

Cavaliers

• G Max Strus (single) out

For the latest updates: Official NBA Injury Report.

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Pistons at Cavaliers picks and predictions

Prediction

Cavaliers 123, Pistons 109

Moneyline

PASSAGE.

There is no value in the Cavaliers (-600) winning on Friday.

Against the spread

LEAN CAVALIERS -10.5 (-115).

Cleveland is going to be a top team in the Eastern Conference this season, while Detroit will most likely be at the bottom. While Cunningham is a dominant player for the Pistons, he won’t be able to keep this game close on his own and will have problems against Mobley as well. Cleveland is a much more complete team and will be able to rally behind the home crowd to easily take on the Pistons.

Top/Bottom

BET ABOVE 227.5 (-115).

The Cavs scored 136 points in their season opener, with six players scoring at least 11. While their shooting performance was spectacular, it should not be expected to be repeated every night. At home, against a Pistons team that has had defensive issues, expect Cleveland to pass most of the load to the Over.

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